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Tooth Development, Mesenchyme, Reciprocal Epithelial, Bud Stage, Cap Stage, Bell Stage, Root Development, Cementoblasts, Cells of Dental Sac, Peridontal Ligament are parts of this lecture layout.
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Teeth - 2 sets form
primary dentition (deciduous or milk teeth)secondary dentition (permanent teeth). General anatomy - Enamel, dentin, dental pulp, boney socket,
periodontal ligament, cementoblast, cememtum. Ectoderm - enamelMesoderm - everything
32 permenant teeth 16 top; 16 bottom 20 with deciduous teeth 10 top; 10 bottommedial, lateral incisors;canine, 1
st^ and 2
nd
premolar 12 w/out deciduous teeth 6 top; 6 bottomst 1 , 2
nd, 3
rd^ molars, rd( molar, wisdom, often fails to developor erupt)
swellings (10 perjaw) that grow intothe mesenchyme Lef1 (lymphoid enhancer factor 1) –defines ectoderm Msx1 – defines mesenchyme BMP4, FGF8 and SHH – induce the mesenchyme to
participate in tooth formation
Formation of the Enamel knot = signaling center Dental mesenchyme controls the specific form of the tooth
BMP-4, BMP-7,FGF-4 and SHH Stimulate proliferation and differentiationof Ameloblast andOdontoblasts
Odontoblast - produce predentin - deposited next to enamel epithelium
Predentin calcifies to become dentinOdontoblast regresses, cytoplasmic extentions remain in dentinPulp cavity is reduced to form the root canal - vessels and nervespass
Ameloblast – Induced by Odontoblasts - produce amelogenins and
enamelins (organic components of enamel). Enamel – 95% inorganic (hydroxyapatite crystals); 5% organic
Epithelial root sheath - contiguous with ameloblast layer
in crown Mesenchymal cells next to this cell layer differentiate
into odontoblasts and secrete predentin –contiguous with crown dentin Cementoblasts (produce cementum) form from inner
cells of the dental sac - cementum covers thesurface of the dentin - cements the root to the jaw Outer cells of dental sac - bone formation - forms the
alveolus (bony socket) and the periodontalligament
