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The Respiratory System: Anatomy, Physiology, and Disorders, Study notes of Anatomy

A comprehensive overview of the human respiratory system, covering its anatomy, physiology, and common disorders. It delves into the functions of the respiratory system, including gas exchange, pulmonary ventilation, and respiratory gas transport. The document also explores the mechanisms of breathing, respiratory volumes, and the control of respiration. Additionally, it discusses respiratory disorders such as copd and lung cancer, highlighting their causes and effects. This resource is valuable for students of biology, anatomy, and physiology, offering a detailed and informative guide to the respiratory system.

Typology: Study notes

2024/2025

Available from 01/11/2025

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C.A.B.M. | 2024
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The Respiratory System
Overview
The respiratory system facilitates the exchange of gases
(oxygen and carbon dioxide) between the blood and the
environment. The major functions include supplying the
body with oxygen and disposing of carbon dioxide. Key
events in respiration are pulmonary ventilation, external
respiration, respiratory gas transport, and internal
respiration.
Organs of the Respiratory System
Nose
Pharynx
Larynx
Trachea
Bronchi
Lungs (alveoli)
Functional Anatomy
Gas exchange occurs only in the alveoli.
Upper respiratory tract: Includes passageways
from the nose to the larynx.
Lower respiratory tract: Includes passageways
from the trachea to the alveoli.
Passageways purify, humidify, and warm
incoming air.
The Nose
Externally visible and serves as the entry point
for air.
Nostrils (nares) lead air into the nasal cavity,
which is divided by the nasal septum.
Olfactory receptors located in the superior
mucosa detect smells.
Respiratory mucosa:
o Moistens air.
o Traps incoming foreign particles.
o Contains enzymes to destroy bacteria.
Nasal conchae:
o Projections increase surface area and air
turbulence.
o Aid in trapping inhaled particles.
Palate separates the nasal cavity from the oral
cavity:
o Hard palate (anterior, bony support).
o Soft palate (posterior, unsupported).
Paranasal sinuses:
o Found in frontal, sphenoid, ethmoid, and
maxillary bones.
o Functions:
Lighten the skull.
Act as resonance chambers for
speech.
Produce mucus.
The Pharynx
Commonly called the throat; muscular
passageway from the nasal cavity to the larynx.
Three regions:
1. Nasopharynx (superior, behind the
nasal cavity); opened by
pharyngotympanic tubes, draining the
middle ear
2. Oropharynx (middle, behind the
mouth).
3. Laryngopharynx (inferior, attached to
the larynx).
Functions:
o Passageway for food and air.
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The Respiratory System Overview The respiratory system facilitates the exchange of gases (oxygen and carbon dioxide) between the blood and the environment. The major functions include supplying the body with oxygen and disposing of carbon dioxide. Key events in respiration are pulmonary ventilation, external respiration, respiratory gas transport, and internal respiration. Organs of the Respiratory System

  • Nose
  • Pharynx
  • Larynx
  • Trachea
  • Bronchi
  • Lungs (alveoli) Functional Anatomy
  • Gas exchange occurs only in the alveoli.
  • Upper respiratory tract : Includes passageways from the nose to the larynx.
  • Lower respiratory tract : Includes passageways from the trachea to the alveoli.
  • Passageways purify, humidify, and warm incoming air. The Nose
  • Externally visible and serves as the entry point for air.
  • Nostrils (nares) lead air into the nasal cavity, which is divided by the nasal septum.
  • Olfactory receptors located in the superior mucosa detect smells.
  • Respiratory mucosa : o Moistens air. o Traps incoming foreign particles. o Contains enzymes to destroy bacteria.
  • Nasal conchae : o Projections increase surface area and air turbulence. o Aid in trapping inhaled particles.
  • Palate separates the nasal cavity from the oral cavity: o Hard palate (anterior, bony support). o Soft palate (posterior, unsupported).
  • Paranasal sinuses : o Found in frontal, sphenoid, ethmoid, and maxillary bones. o Functions: ▪ Lighten the skull. ▪ Act as resonance chambers for speech. ▪ Produce mucus. The Pharynx
  • Commonly called the throat ; muscular passageway from the nasal cavity to the larynx.
  • Three regions:
  1. Nasopharynx (superior, behind the nasal cavity); opened by pharyngotympanic tubes, draining the middle ear
  2. Oropharynx (middle, behind the mouth).
  3. Laryngopharynx (inferior, attached to the larynx).
  • Functions: o Passageway for food and air.

o Epiglottis routes food to the esophagus and air to the trachea; Oro and lary serve as common passageway

  • Tonsils : o Pharyngeal tonsil (adenoid): Located in the nasopharynx. o Palatine tonsils: Located at the end of the soft palate. o Lingual tonsils: Located at the base of the tongue. The Larynx
  • Commonly called the voice box ; located inferior to the pharynx.
  • Composed of 8 rigid hyaline cartilages and the elastic epiglottis.
  • Functions : o Routes air and food into proper channels. o Plays a role in speech.
  • Epiglottis : o Protects the superior opening of the larynx. o Forms a lid during swallowing to prevent food from entering the respiratory tract.
  • Vocal cords (vocal folds) : o Vibrate to produce sound. o The glottis is the opening between the vocal cords. The Trachea
  • Commonly called the windpipe ; a 4-inch tube connecting the larynx to the bronchi.
  • Reinforced with C-shaped hyaline cartilage to keep it open.
  • Lined with ciliated mucosa : o Cilia move debris-laden mucus away from the lungs. o Beat continuously in the opposite direction of incoming air. The Bronchi and Lungs Main Bronchi
  • Formed by the division of the trachea.
  • Each bronchus enters the lung at the hilum.
  • Right bronchus is wider, shorter, and straighter than the left.
  • Branch into smaller passageways. Lungs
  • Occupy the thoracic cavity except for the central mediastinum.
  • Apex: Near the clavicle.
  • Base: Rests on the diaphragm.
  • Lobes : o Left lung: Two lobes. o Right lung: Three lobes.
  • Serosa covers the outer surface of the lungs o Pulmonary (visceral) pleura covers the lung surface o Parietal pleura lines the walls of the thoracic cavity
  • Pleural fluid fills the area between layers o Allows the lungs to glide over the thorax o Decreases friction during breathing
  • Pleural space (between the layers) is more of a potential space

Respiratory Physiology

  • Functions o Supply the blood with oxygen o Dispose of carbon dioxide Four Events of Respiration
    1. Pulmonary Ventilation : o Moving air in and out of lungs (breathing).
    2. External Respiration : o Gas exchange between pulmonary blood and alveoli. ▪ Oxygen is loaded into the blood ▪ Carbon dioxide is unloaded from the blood
    3. Respiratory Gas Transport : o Transport of oxygen and carbon dioxide in the bloodstream.
    4. Internal Respiration : o Gas exchange between blood and tissue cells in systemic capillaries. Mechanics of Breathing
  • Pulmonary ventilation o Mechanical process that depends on volume changes in the thoracic cavity o Rule: Volume changes lead to pressure changes, which lead to the flow of gases to equalize pressure
  • Two phases : o Inspiration = inhalation (flow of air into the lungs) o Expiration = Exhalation (air leaving lungs)
    1. Inspiration (inhalation) : o Diaphragm and intercostal muscles contract, increasing thoracic cavity volume. o Air flows in as pressure decreases.
    2. Expiration (exhalation) : o Largely passive; depends on lung elasticity. o Air flows out as pressure increases.
    3. Intrapleural pressure : o Always negative; prevents lung collapse. Respiratory Volumes - Factors affecting respiratory capacity o Size o Sex o Age o Physical condition - Tidal Volume (TV): Normal breath (~500 ml). - Inspiratory Reserve Volume (IRV): Additional air inhaled forcibly over TV (~3, ml).
  • Expiratory Reserve Volume (ERV): Additional air exhaled forcibly (~1,200 ml).
  • Residual Volume: Air remaining after tidal expiration (~1,200 ml). o Cannot be voluntarily exhaled o Allows gas exchange to go on continuously, even between breaths, and helps keep alveoli open (inflated)
  • Vital Capacity (VC): TV + IRV + ERV (~4,800 ml in men). o The total amount of exchangeable air
  • Dead space volume o Air that remains in conducting zone and never reaches the alveoli (~150 ml)
  • Functional volume o Air that actually reaches the respiratory zone (~350 ml) Respiratory capacities are measured with a spirometer. Insert pic Nonrespiratory Air Movements
  • Can be caused by reflexes or voluntary actions
  • Examples o Cough and sneeze—clears lungs of debris o Crying—emotionally induced mechanism o Laughing—similar to crying o Hiccup—sudden inspirations o Yawn—very deep inspiration Respiratory Sounds
  • Sounds are monitored with a stethoscope
  • Two recognizable sounds can be heard with a stethoscope:
  1. Bronchial sounds —produced by air rushing through large passageways such as the trachea and bronchi 2. Vesicular breathing sounds —soft sounds of air filling alveoli External Respiration, Gas Transport, and Internal Respiration
  • Gas exchanges occur as a result of diffusion o External respiration is an exchange of gases occurring between the alveoli and pulmonary blood (pulmonary gas exchange) o Internal respiration is an exchange of gases occurring between the blood and tissue cells (systemic capillary gas exchange)
  • Movement of the gas is toward the area of lower concentration External Respiration
  • Oxygen is loaded into the blood o Oxygen diffuses from the oxygen-rich air of the alveoli to the oxygen-poor blood of the pulmonary capillaries
  • Carbon dioxide is unloaded out of the blood o Carbon dioxide diffuses from the blood of the pulmonary capillaries to the alveoli

o Oxygen is the stimulus for those whose systems have become accustomed to high levels of carbon dioxide as a result of disease o Hyperventilation ▪ Rising levels of CO2 in the blood (acidosis) result in faster, deeper breathing ▪ Exhale more CO2 to elevate blood pH ▪ May result in apnea and dizziness and lead to alkalosis o Hypoventilation ▪ Results when blood becomes alkaline (alkalosis) ▪ Extremely slow or shallow breathing ▪ Allows CO2 to accumulate in the blood Respiratory Disorders

  • Chronic Obstructive Pulmonary Disease (COPD): o Includes chronic bronchitis and emphysema. o Common in smokers; leads to respiratory failure.
  • Asthma: o Hypersensitivity of bronchioles leading to dyspnea, coughing, and wheezing.
  • Lung Cancer: o Leading cause of cancer death; often linked to smoking. o Three common types: Adenocarcinoma, squamous cell carcinoma, small cell carcinoma Developmental Aspects - Newborns: Lungs inflate within 2 weeks after birth. - Aging Effects: o Decreased lung elasticity and vital capacity. o Increased susceptibility to respiratory infections. - Respiratory rate changes throughout life o Newborns: 40 to 80 respirations per minute o Infants: 30 respirations per minute o Age 5: 25 respirations per minute o Adults: 12 to 18 respirations per minute o Rate often increases again in old age Reference: Marieb, E. N., & Keller, S. (2018). Essentials of human anatomy & physiology (12th ed., pp. 462 – 483 ). Pearson Education, Inc.