Pharmacy Notes For Pharmacists, Study Guides, Projects, Research of Pharmacology

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TABLE 133 | typical Values of Chemical Shits Type of Proton Approximate 5 Type of Proton Approximate 5 alkane (—CH3) 0.9 Ne=cZ C=C 17 mehy) ~ allylic “CH, alkane (—CH,—) 13 Ph—H : 7.2 methylene aromatic alkane (-E-) 14 hae” *8 methine ? R—C—H 9-10 || aldehyde —C—CH, 21 methyl ketone i —c=c—H 25 R—C—OH 10-12 acetylenic R—OH variable, about 2-5 R—CH,—x 3-4 alcohol (X = halogen, O) Ar—OH variable, about 4-7 phenol N a = CL 5-6 R—NH) variable, about 1.5—4 vinyl! H amine Note: These values are approximate, as all chemical shifts are affected by neighboring substituents. The numbers given here assume that alkyl groups are the only other substituents present. A more complete table of chemical shifts appears in Appendix 1. (©2012 Pearson Esato, ne. Approx. J Approx. J | | HO —C—C— (free rotation) 7 Hz* 8 Hz | | H H 4H (ortho) Z Aa (cis) 10 Hz H H H : 2Hz H N Z H C=C (trans) 15 Hz Z Ss (meta) H Nar H Cc \ oe SS oS C=C (geminal) 2Hz C=C H 6Hz a SS H Z Ss H (allylic)