RISK FACTORS
Preeclampsia in First Pregnancy
Family history of pre-eclampsia and hypertension
Stress
Inappropriate vascular remodeling
Ischemic /Hypoperfuse placenta
Defective cytotrophoblast
Increased secretion of angiogenic factor
Invasion of maternal spiral arteries
Deficient transformation of spiral arterioles
Reduced placental perfusion
Proangiogenic effect of vascular endothelial growth (VEGF)
Vascular endothelial dysfunction
Reduced blood flow to organs
Increased ET-1 & ROS,
decreased NO & PG12
Hypertension Renal pressure natriuresis
Proteinuria
Pre-eclampsia
Intrauterine growth restrictions
Preterm Birth/Prematurity
FETAL PATHOLOGY
Inadequate Surfactant
Structurally Imature Lung Low Birth Weight
Respiratory Distress Syndrome
Apnea
Bradycardia
Grunting
Nasal flaring
Cyanosis
