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Human Nervous, Endocrine, and Cardiovascular Systems: A Comprehensive Overview, Study notes of Anatomy

A comprehensive overview of the human nervous system, including its branches, functions, and neurotransmitters. It also delves into the endocrine system, covering various hormones, their functions, and conditions caused by hormonal imbalances. Additionally, it explores blood components, their normal values, and conditions associated with high and low levels. Finally, the document examines the cardiovascular system, including the heart's structure, function, and common cardiovascular diseases.

Typology: Study notes

2024/2025

Uploaded on 03/08/2025

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Branches of Nervous System and its functions
Central nervous system (CNS)
Brain and Spinal cord Acts as integrating and command center
interpret incoming sensory information and issue instructions based on past experiences and current conditions.
Peripheral nervous system (PNS)
Nerves outside the brain and spinal cord Link a parts of the body by carrying impulses to the CNS and back
- Sensory (aerent) division Nerve bers that carry information to the central nervous system
- Motor (eerent) division Nerve bers that carry impulses away from the central nervous system
- Two subdivisions
- Somatic nervous system = voluntary nervous system
Skeletal muscle reexes such as stretch reex are initiated involuntarily by same bers
- Autonomic nervous system = involuntary nervous system Sympathetic and parasympathetic divisions
Neurotransmitters: functions and abnormal conditions. (Dopamine, Serotonin, Acetylcholine, Epi and Norepi,
etc)--
Neurotransmitter is released from a nerves axon terminal
The dendrite of the next neuron has receptors that are stimulated by the neurotransmitter
An action potential is started in the dendrites of the next neuron
Transmission of an impulse is an electrochemical event
Acetylcholine
- Muscle contractions, memory, motivation, sexual desire, sleep and learning. Imbalances in
acetylcholine levels are linked with health issues, including Alzheimers disease, seizures and muscle spasms.
Endorphins
- Release of endorphins reduces pain, as we as causes feel good feelings. Low levels of endorphins may
play a role in bromyalgia and some types of headaches.
Dopamine
- Dopamine is a brain chemical involved in pleasure, motivation, and learning. It also helps with focus,
memory, mood, and sleep. Problems with dopamine can lead to conditions like Parkinsons disease, schizophrenia,
bipolar disorder, restless legs syndrome, and ADHD.
Epinephrine
- Epinephrine, or adrenaline, triggers the "ght-or-ight" response during fear or stress. It raises your
heart rate, breathing, blood pressure, blood sugar, and sharpens focus to help you react quickly. Too much epinephrine
can lead to health problems like high blood pressure, diabetes, and heart disease.
Glutamate
- Glutamate is the brain's most common neurotransmitter that helps with thinking, learning, and memory.
If glutamate levels are o balance, it can be linked to conditions like Alzheimers, dementia, Parkinsons disease, and
seizures.
Glycine
- Glycine is involved in controing hearing processing, pain transmission and metabolism.
Gamma-aminobutyric acid (GABA)
- Regulates brain activity
Histamine
- Histamine helps control wakefulness, appetite, and motivation. It’s also involved in conditions like asthma,
breathing issues, sweing, and multiple sclerosis.
Norepinephrine
- Raises blood pressure and heart rate. It helps with alertness, focus, decision-making, and attention.
Too much norepinephrine can cause high blood pressure, a fast or irregular heartbeat, and excessive sweating.
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Branches of Nervous System and its functions–

Central nervous system (CNS) Brain and Spinal cord Acts as integrating and command center

  • interpret incoming sensory information and issue instructions based on past experiences and current conditions. Peripheral nervous system (PNS) Nerves outside the brain and spinal cord Link a parts of the body by carrying impulses to the CNS and back
  • Sensory (aerent) division Nerve bers that carry information to the central nervous system
  • Motor (eerent) division Nerve bers that carry impulses away from the central nervous system
  • Two subdivisions
  • Somatic nervous system = voluntary nervous system Skeletal muscle reexes such as stretch reex are initiated involuntarily by same bers
  • Autonomic nervous system = involuntary nervous system Sympathetic and parasympathetic divisions

Neurotransmitters: functions and abnormal conditions. (Dopamine, Serotonin, Acetylcholine, Epi and Norepi,

etc)--

Neurotransmitter is released from a nerve’s axon terminal The dendrite of the next neuron has receptors that are stimulated by the neurotransmitter An action potential is started in the dendrites of the next neuron Transmission of an impulse is an electrochemical event Acetylcholine - Muscle contractions, memory, motivation, sexual desire, sleep and learning. Imbalances in acetylcholine levels are linked with health issues, including Alzheimer’s disease, seizures and muscle spasms. Endorphins - Release of endorphins reduces pain, as we as causes “feel good” feelings. Low levels of endorphins may play a role in bromyalgia and some types of headaches. Dopamine - Dopamine is a brain chemical involved in pleasure, motivation, and learning. It also helps with focus, memory, mood, and sleep. Problems with dopamine can lead to conditions like Parkinson’s disease, schizophrenia, bipolar disorder, restless legs syndrome, and ADHD. Epinephrine - Epinephrine, or adrenaline, triggers the "ght-or-ight" response during fear or stress. It raises your heart rate, breathing, blood pressure, blood sugar, and sharpens focus to help you react quickly. Too much epinephrine can lead to health problems like high blood pressure, diabetes, and heart disease. Glutamate - Glutamate is the brain's most common neurotransmitter that helps with thinking, learning, and memory. If glutamate levels are o balance, it can be linked to conditions like Alzheimer’s, dementia, Parkinson’s disease, and seizures. Glycine - Glycine is involved in controing hearing processing, pain transmission and metabolism. Gamma-aminobutyric acid (GABA) - Regulates brain activity Histamine - Histamine helps control wakefulness, appetite, and motivation. It’s also involved in conditions like asthma, breathing issues, sweing, and multiple sclerosis. Norepinephrine - Raises blood pressure and heart rate. It helps with alertness, focus, decision-making, and attention. Too much norepinephrine can cause high blood pressure, a fast or irregular heartbeat, and excessive sweating.

Serotonin - Serotonin helps control mood, sleep, anxiety, appetite, and pain. When serotonin is out of balance, it can lead to conditions like anxiety, depression, seasonal aective disorder, bromyalgia, and chronic pain.

Lobes of the brain and its functions–

Frontal lobe - help control thinking, planning, organizing, problem-solving, short-term memory and movement. Process images from your eyes and connect them to the images stored in your memory. This aows you to recognize images. Parietal lobe - help interpret feelings, known as sensory information. The lobes process taste, texture and temperature. Occipital lobe - process images from your eyes and connect them to the images stored in your memory. This aows you to recognize images. Temporal lobe - help process information from your senses of sme, taste and sound. They also play a role in memory storage.

Cerebrospinal Fluid (CSF)--

  • Forms a watery cushion to protect the brain
  • Is a ltered form of blood plasma found in the brain's ventricles and around the brain and spine. It nourishes the brain, removes waste, and protects it.

Parasympathetic vs Sympathetic–

Sympathetic division – mobilizes the body Parasympathetic division

  • aows body to unwind
  • housekeeping activities, Conserves energy, Maintains daily necessary body functions
  • Remember as the “D” division - digestion, defecation, and diuresis
  • Heart rate slows down, Normal breathing rate, pupils constrict Sympathetic division
  • “ght-or-ight”
  • Response to unusual stimulus
  • Takes over to increase activities
  • Remember as the “E” division = exercise, excitement, emergency, and embarrassment
  • Hearts racing, pupils dilate, airways open, stomach and intestines stop digesting, reproductive system limits blood ow.

Types of hearing loss: Conductive, Sensorineural, and mixed–

  1. Conductive hearing loss: This type occurs when sound cannot eiciently travel through the outer ear canal to the eardrum and the tiny bones of the middle ear, often due to blockages or damage.
  2. Sensorineural hearing loss: This type results from damage to the inner ear or the auditory nerve, aecting the ability to hear faint sounds and understand speech, often due to aging, noise exposure, or genetic factors.
  3. Mixed hearing loss: This type is a combination of conductive and sensorineural hearing loss, indicating that there are issues in both the outer/middle ear and the inner ear or auditory nerve.

Eustachian tube–

  • Eustachian tubes connect your middle ears to the back of your throat. The tubes help drain uid from your middle ear and balance air pressure inside your ears.
  • Aows for equalizing pressure during yawning or swaowing – This tube is otherwise coapsed

Hormones and its functions–

  1. Adrenaline (Epinephrine) - Increases heart rate, blood ow, and energy during the "ght-or-ight" response.
  2. Aldosterone - Regulates sodium and potassium levels in the blood, aecting blood pressure and uid balance.
  3. Androgens (e.g., Testosterone) -Male sex hormones that promote the development of male reproductive tissues and secondary sexual characteristics.
  4. Antidiuretic Hormone (ADH, Vasopressin) - Regulates water retention in the kidneys and helps control blood pressure.
  5. Calcitonin - Lowers blood calcium levels by inhibiting osteoclast activity in the bones.
  6. Cortisol - A stress hormone that regulates metabolism, immune response, and blood pressure.
  7. Estrogens (e.g., Estradiol) - Female sex hormones that regulate the menstrual cycle and promote the development of female reproductive organs.
  8. Foicle-Stimulating Hormone (FSH) - Stimulates the growth of ovarian foicles in females and sperm production in males.
  9. Gonadotropin-Releasing Hormone (GnRH) - Stimulates the release of FSH and luteinizing hormone (LH) from the pituitary gland.
  10. Growth Hormone (GH) -Stimulates growth, ce reproduction, and regeneration.
  11. Insulin - Regulates blood glucose levels by facilitating glucose uptake into ces.
  12. Leptin - Regulates energy balance and body weight by inhibiting hunger.
  13. Luteinizing Hormone (LH) - Triggers ovulation in females and stimulates testosterone production in males.
  14. Melatonin - Regulates sleep-wake cycles and circadian rhythms.
  15. Norepinephrine (Noradrenaline) - Aects attention and response actions in the brain and increases heart rate and blood pressure.
  16. Oxytocin -Promotes social bonding, sexual reproduction, and childbirth processes like uterine contractions and milk ejection.
  1. Parathyroid Hormone (PTH) - Increases blood calcium levels by stimulating osteoclasts and promoting calcium reabsorption in the kidneys.
  2. Progesterone - Prepares the uterus for pregnancy and helps maintain it during pregnancy.
  3. Prolactin - Stimulates milk production in breastfeeding women and regulates other reproductive functions.
  4. Thyroid Hormones (T3 and T4) - Regulate metabolism, energy production, and growth and development.
  5. Thyroid-Stimulating Hormone (TSH) - Stimulates the thyroid gland to produce thyroid hormones.
  6. Vasopressin (Antidiuretic Hormone) - Regulates water retention in the kidneys and helps control blood pressure.
  7. Human Chorionic Gonadotropin (hCG) - Produced during pregnancy, it helps maintain the corpus luteum and promotes progesterone production.
  8. Erythropoietin (EPO) - Stimulates red blood ce production in response to low oxygen levels.

Conditions caused by abnormalities of hormone levels, their causes, and common interventions–

  1. Diabetes Meitus - A condition characterized by high blood sugar levels due to insuicient insulin production (Type 1) or insulin resistance (Type 2). Causes include genetic factors, obesity, and sedentary lifestyle. - Monitor blood levels regularly & Provide education on insulin administration techniques
  2. Cushing's Syndrome - Caused by excessive cortisol levels, leading to symptoms such as weight gain, high blood pressure, and skin changes. It can result from pituitary tumors (Cushing's disease), adrenal tumors, or prolonged use of corticosteroid medications. - Monitor vital signs and assess for signs of hypertension and cardiovascular complications due to excess cortisol.
  3. Hypothyroidism - A condition where the thyroid gland produces insuicient thyroid hormones, leading to fatigue, weight gain, and depression. Common causes include autoimmune diseases like Hashimoto's thyroiditis and iodine deciency. - Monitor thyroid hormone levels and assess for symptoms such as increased heart rate, weight loss, and anxiety.
  4. Hyperthyroidism - An excess of thyroid hormones in the body, causing symptoms such as weight loss, rapid heartbeat, and anxiety. Often caused by Graves' disease, thyroid nodules, or excessive iodine intake. - Monitor thyroid hormone levels and assess for symptoms such as increased heart rate, weight loss, and anxiety.
  5. Addison's Disease - A disorder resulting from insuicient production of cortisol and aldosterone, leading to fatigue, weight loss, and low blood pressure. Causes include autoimmune destruction of the adrenal glands or infections like tuberculosis. - Monitor electrolyte levels, particularly sodium and potassium, and teach the patient about dietary needs to maintain balance.
  1. Testosterone Deciency (Low T) - A condition where men have low levels of testosterone, leading to reduced libido, fatigue, and depression. Causes can include aging, pituitary gland disorders, or testicular damage.
    • Assess symptoms of testosterone deciency, such as fatigue and decreased libido, and monitor hormone levels.
  2. Congenital Adrenal Hyperplasia (CAH) - A genetic disorder aecting adrenal hormone production, leading to excess androgens and symptoms like ambiguous genitalia in newborn girls and early puberty in boys. It is caused by mutations in genes responsible for adrenal enzyme production.
    • Monitor growth and development in aected children and educate families about managing hormone replacement therapy.

Levothyroxine–

  • Levothyroxine is a medicine used to treat an underactive thyroid gland (hypothyroidism).
  • The thyroid gland makes thyroid hormones which help to control energy levels and growth. Levothyroxine is taken to replace the missing thyroid hormone thyroxine.

Acromegaly–

  • Acromegaly is a hormonal disorder that occurs when the pituitary gland produces excessive growth hormone in adulthood. This excess leads to enlarged bones and tissues, and if it occurs in childhood, it results in increased height, a condition known as gigantism.

Diabetic Ketoacidosis–

  • This condition occurs when the body cannot produce enough insulin, which is essential for aowing sugar to enter ces and serve as energy. Without suicient insulin, the body breaks down fat for fuel, leading to a buildup of acids caed ketones in the bloodstream. If untreated, this can result in diabetic ketoacidosis, a serious and potentiay life-threatening complication.

CBC and indications of high and low levels of the CBC components–

● Anemia (low levels of red blood ces or hemoglobin). ● Erythrocytosis (high concentrations of red blood ces). ● Leukocytosis (high white blood count). ● Leukopenia (low white blood count). ● Thrombocytosis (high platelet count). ● Thrombocytopenia (low platelet count).

Normal values of Blood components and conditions from high and low levels. Interventions for these

conditions–

  • Erythrocytes(Red Blood Ces)
    • Normal Values: Men: 4.7 - 6.1 miion ces/μL Women: 4.2 - 5.4 miion ces/μL High Levels: Dehydration, polycythemia Low Levels: Anemia, blood loss Interventions: Iron supplements, hydration, blood transfusions (if severe).
  • Leukocyte(White Blood Ces)
    • Normal levels =4,000 to 11,000 ces/ml High Levels: Infection, inammation Low Levels: Bone marrow disorders, autoimmune diseases Interventions: Treat infection, manage underlying condition, medications to stimulate bone marrow.
  • Hemoglobin (Hgb)
    • Normal Values: Men: 13.8 - 17.2 g/dL Women: 12.1 - 15.1 g/dL High Levels: Polycythemia, COPD Low Levels: Anemia Interventions: Iron therapy, vitamin B12/folate supplementation, blood transfusions.
  • Platelets
    • Normal Values: 300,000/mm High Levels: Inammation, infection Low Levels: Thrombocytopenia, bone marrow disorders Interventions: Manage underlying cause, platelet transfusions (if severe).

Types of Anemia–

  1. Iron Deciency Anemia Cause: Lack of iron. Symptoms: Fatigue, weakness, pale skin.
  2. Vitamin B12 Deciency Anemia Cause: Insuicient vitamin B12 (poor absorption). Symptoms: Fatigue, weakness, nerve problems (tingling or numbness).

Blood Typing (ABO and RH) and Blood Transfusion–

  • Blood samples are mixed with anti-A and anti-B serum
  • Coagulation or no coagulation leads to determining blood type
  • Typing for ABO and Rh factors is done in the same manner
  • Cross matching – testing for agglutination of donor RBCs by the recipient’s serum, and vice versa

Blood Flow–

Conduction of Heart’s electrical impulse

I. Sinoatrial Node (SA Node): The electrical impulse starts in the SA node (the heart's natural pacemaker), located in the right atrium. II. Atria: The impulse spreads through the atria, causing them to contract and push blood into the ventricles. III. Atrioventricular Node (AV Node): The impulse then travels to the AV node, which briey pauses it to aow the ventricles to with blood. IV. Bundle of His: The impulse moves from the AV node to the Bundle of His, which divides into right and left bundle branches. V. Purkinje Fibers: Finay, the impulse travels through Purkinje bers, causing the ventricles to contract and pump blood to the lungs and the rest of the body.

Basic ECG principles: Ventricular depolarization V depolarization and others–

I. P Wave: Represents atrial depolarization, the electrical activity that causes the atria to contract and push blood into the ventricles. II. QRS Complex: Represents ventricular depolarization, the electrical activity that triggers the ventricles to contract and pump blood to the lungs and body. This complex is typicay sharp and ta. III. T Wave: Represents ventricular repolarization, the process of the ventricles recovering after contraction and preparing for the next heartbeat. IV. PR Interval: The time between the end of atrial depolarization and the beginning of ventricular depolarization. It indicates the delay at the AV node. V. QT Interval: The time from the start of ventricular depolarization to the end of ventric

LUB DUB, S1 S2, Systole and Diastole–

I. LUB (S1): This is the rst heart sound, caused by the closing of the atrioventricular (AV) valves (mitral and tricuspid) when the ventricles contract (systole). II. DUB (S2): This is the second heart sound, caused by the closing of the semilunar valves (aortic and pulmonary) when the ventricles relax (diastole). III. Systole: The phase of the cardiac cycle when the heart muscles contract, pumping blood out of the ventricles. IV. Diastole: The phase of the cardiac cycle when the heart muscles relax, aowing the chambers to with blood.

Normal Vital signs and terms for low and high values–

  1. Blood Pressure Normal: 120/80 mmHg Low: Hypotension High: Hypertension
  2. Heart Rate (Pulse) Normal: 60-100 beats per minute (bpm) Low: Bradycardia High: Tachycardia
  3. Respiratory Rate Normal: 12-20 breaths per minute Low: Bradypnea High: Tachypnea
  4. Temperature Normal: 36.5-37.5C Low: Hypothermia High: Hyperthermia

Myocarditis–

● Denition: Inammation of the heart muscle (myocardium).

Endocarditis–

● Denition: Infection and inammation of the inner lining of the heart (endocardium) and heart valves.

Fibriation–

  • lack of blood ow to the heart

Cardiac Tamponade

- A condition where uid accumulates in the pericardial sac surrounding the heart, causing pressure that

impairs the heart's ability to pump eectively.