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Study Guide: Exam II—PSYCH 259 -- Fall 2023 Mood Disorders Major Depressive Disorder - A disorder in which the individual experiences acute but time-limited episodes of depressive symptoms. Major mood states in the mood disorders – Dysphoria (elevated sad mood) and Euphoria (more cheerful and elated than average) What is dysphoria—p. 168 – An unusually elevated sad mood. Duration of symptoms – at least 2 weeks Gender differences in symptoms – Men (angry, irritate) and Women (Sadness) Sleep disruption – Chronic Insomnia is most common. Ultimate cause of bipolar disorder – genetic condition – imbalance in neurotransmitter. Symptoms in preadolescent children-
o instead of diagnosing depression in children one would diagnose this. A depressive disorder in children who exhibit chronic and severe irritability and have frequent temper outbursts. Bereavement vs Major Depressive Disorder -
Gender Differences in response to antidepressant medication - WOMEN - more effective when Estrogen Present. Younger women respond better than post- menopausal females to antidepressant meds. MEN – men don’t respond as well to meds as women do, May do better with meds that target norepinephrine. Adjunctive medication – Rexulti acts on both dopamine and serotonin. Abilify – used to increase effectiveness of SSRIs. Education of patients and family so patient can take meds on time. – Best Therapy. – used in addition to primary one. Psychotherapy of choice – Cognitive behavioral therapy and interpersonal. Behavioral Activation – Behavioral therapy for depression in which the clinician helps the client identify activities associated with positive mood. Underlying assumption of cognitive therapy – depression is due to distorted/dysfunctional thoughts. Techniques of cognitive therapy— CBT also focuses on the client’s dysfunctional thoughts and how to modify them through cognitive restructuring. Mindfulness training, as an additional component of cognitive-behavioral intervention, can help clients develop a greater sense of self-efficacy, an added boost to its positive effects on mood. Prime focus Is on present and now not on past factors. TM Interpersonal Psychotherapy—key assumptions – people who cannot take antidepressant meds can go for this. Focuses on the idea that a person’s depression comes from stress from relationships; stress can lead to appearance of this disorder in those who are biologically predisposed towards it TMRS therapy for Major Depressive Disorder- uses magnetic pulse to stimulate brain cells that control mood. Pulses focused on limbic structures causing neurons to become active. Used for moderate depression. Vagal stimulation – used for severe Major depressive disorder. Electrode in Video from class—Edward’s cognitive distortions - Overgeneralization / catostrophization. Time required for antidepressants to be associated with mood improvement— 2 to 6 weeks. Treatment for Seasonal Affective Disorder Mechanism of action of first generation (Tricyclic) antidepressant medication— inhibit reuptake of serotonin and norepinephrine. Neurotransmitter reuptake is the process by which neurotransmitters are taken back up into the neurons after they have been released into the synapse (the gap between two neurons). By blocking this reuptake, TCAs increase the concentration of these neurotransmitters in the synapse. By increasing the levels of serotonin and norepinephrine in the synaptic cleft, TCAs help
improve communication between neurons. – Act on both Serotonin and enephineprine – Same effective but less side effects. “File drawer problem”— the fact that investigators are likely to file away, and not even submit for publication, studies that fail to establish significant benefits. Dysthymic Disorder (Persistent Depressive Disorder) - Chronic but less severe mood disturbance in which the individual does not experience a major depressive episode. SAD (seasonal affective disorder)- happens particular time of year – for lasting more than 2 years. Dysthymic disorder vs. Major Depressive Disorder—difference - Persistent Depressive Disorder
Difficulties in diagnosing mania in children Events that can trigger manic episode - Distorted sleep schedule; stressful or conflictive family life Which mood disorder has greatest heritability? – Bipolar Disorder Two factor theory of neurotransmitters - if you have MDD you have low levels of both neurotransmitter , if you have bipolar low serotonin and high norepinephrine. Bipolar Disorder and creativity – Many artists create best work in manic episodes (usually hypomanic)
Suicide North America and Europe—percentage of individuals who kill themselves that have a diagnosable mental health problem— 90 %
Parasuicide – Attempt for suicide – as seen as call for help. Most common method of effected (completed) suicide – Firearms. Most common method of attempted suicide – Drug Overdose or Poisoning.
Ethnicity with highest suicide rates in early adulthood – Whites and Native Americans Characteristics of persons effecting suicide—
Alcohol use and suicide— Alcohol use leads to 90% increase in Suicide. Legality and Prevalence of Physician Assisted Suicide – Oregon USA and High percentage is due to physician assisted suicide.