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Comprehensive Rheumatology: Autoimmune Disorders, Inflammatory Arthritis, and Connective T, Exams of Nursing

Queen Mary, University of London (QMUL)Nursing

Comprehensive Rheumatology: Autoimmune Disorders, Inflammatory Arthritis, and Connective Tissue Diseases.

Typology: Exams

2024/2025

Available from 07/04/2025

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Comprehensive Rheumatology: Autoimmune
Disorders, Inflammatory Arthritis, and
Connective Tissue Diseases
1. A 40-year-old woman has symmetrical swelling and tenderness of
the metacarpophalangeal (MCP) and wrist joints lasting over 6
weeks. What is the most likely diagnosis?
A) Osteoarthritis
B) Rheumatoid arthritis
C) Gout
D) Lupus
2. Which antibody is most specific for rheumatoid arthritis?
A) ANA
B) RF
C) Anti-CCP antibody
D) Anti-dsDNA
3. Morning stiffness lasting more than 1 hour is characteristic of:
A) Osteoarthritis
B) Rheumatoid arthritis
C) Fibromyalgia
D) Gout
4. What is the first-line disease-modifying antirheumatic drug
(DMARD) for rheumatoid arthritis?
A) Sulfasalazine
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Comprehensive Rheumatology: Autoimmune

Disorders, Inflammatory Arthritis, and

Connective Tissue Diseases

  1. A 40-year-old woman has symmetrical swelling and tenderness of the metacarpophalangeal (MCP) and wrist joints lasting over 6 weeks. What is the most likely diagnosis?  A) Osteoarthritis  B) Rheumatoid arthritis  C) Gout  D) Lupus
  2. Which antibody is most specific for rheumatoid arthritis?  A) ANA  B) RF  C) Anti-CCP antibody  D) Anti-dsDNA
  3. Morning stiffness lasting more than 1 hour is characteristic of:  A) Osteoarthritis  B) Rheumatoid arthritis  C) Fibromyalgia  D) Gout
  4. What is the first-line disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis?  A) Sulfasalazine

 B) Hydroxychloroquine  C) Leflunomide  D) Methotrexate

  1. Which of the following is a poor prognostic factor in rheumatoid arthritis?  A) Negative rheumatoid factor  B) Mild joint involvement  C) Presence of subcutaneous nodules  D) Early treatment
  2. Which condition is characterized by uric acid crystal deposition in joints?  A) Rheumatoid arthritis  B) Osteoarthritis  C) Gout  D) Psoriatic arthritis
  3. Which joint is most commonly affected in osteoarthritis?  A) MCP joint  B) Wrist  C) Distal interphalangeal joint (DIP)  D) Elbow
  4. The hallmark of systemic lupus erythematosus (SLE) is:  A) Anti-CCP antibody  B) Positive antinuclear antibody (ANA)

 D) Oral ulcers

  1. Which disease is characterized by fibrosis of skin and internal organs?  A) SLE  B) Rheumatoid arthritis  C) Systemic sclerosis (scleroderma)  D) Sjögren’s syndrome
  2. Raynaud’s phenomenon is most commonly associated with:  A) Osteoarthritis  B) Systemic sclerosis  C) Gout  D) Fibromyalgia
  3. Which antibody is associated with limited cutaneous systemic sclerosis?  A) Anti-dsDNA  B) Anti-CCP  C) Anti-centromere antibody  D) Anti-RNP
  4. Which autoimmune disease primarily affects exocrine glands causing dry mouth and dry eyes?  A) SLE  B) Sjögren’s syndrome  C) Rheumatoid arthritis

 D) Polymyositis

  1. Which test is used to diagnose Sjögren’s syndrome?  A) Rheumatoid factor  B) Anti-CCP antibody  C) Anti-Ro (SSA) and Anti-La (SSB) antibodies  D) Anti-dsDNA
  2. Which disease is characterized by proximal muscle weakness and elevated muscle enzymes?  A) Fibromyalgia  B) Polymyalgia rheumatica  C) Polymyositis  D) Osteoarthritis
  3. Which of the following is a classic feature of ankylosing spondylitis?  A) Peripheral arthritis  B) Inflammatory back pain with morning stiffness  C) Rash  D) Raynaud’s phenomenon
  4. Which HLA type is strongly associated with ankylosing spondylitis?  A) HLA-DR  B) HLA-B  C) HLA-DR
  1. Which of the following is a seronegative spondyloarthropathy?  A) Rheumatoid arthritis  B) Psoriatic arthritis  C) SLE  D) Sjögren’s syndrome
  2. Which skin lesion is characteristic of psoriatic arthritis?  A) Malar rash  B) Silvery scaly plaques on extensor surfaces  C) Butterfly rash  D) Oral ulcers
  3. Which joint pattern is typical of psoriatic arthritis?  A) Symmetrical small joint involvement  B) Asymmetrical oligoarthritis  C) Large joint monoarthritis only  D) Distal interphalangeal joint sparing
  4. Which test is most useful in diagnosing giant cell arteritis?  A) ANA  B) Temporal artery biopsy  C) Rheumatoid factor  D) Anti-CCP antibody
  5. Which condition is characterized by inflammation of the synovium leading to joint destruction?

 A) Osteoarthritis  B) Rheumatoid arthritis  C) Gout  D) Fibromyalgia

  1. Which of the following is a common extra-articular manifestation of rheumatoid arthritis?  A) Oral ulcers  B) Subcutaneous rheumatoid nodules  C) Photosensitivity  D) Dry eyes
  2. Which antibody is most commonly positive in mixed connective tissue disease (MCTD)?  A) Anti-dsDNA  B) Anti-CCP  C) Anti-U1 RNP antibody  D) Anti-Ro
  3. Which medication class is commonly used to treat vasculitis?  A) NSAIDs  B) Corticosteroids  C) Antibiotics  D) Antimalarials
  4. Which of the following is a feature of fibromyalgia?  A) Joint swelling

 C) Polyarteritis nodosa  D) Kawasaki disease

  1. Which of the following is the first-line treatment for osteoarthritis?  A) DMARDs  B) Weight loss and exercise  C) Corticosteroids  D) Methotrexate
  2. Which of the following is a common site of osteoarthritis?  A) MCP joints  B) Knees and hips  C) Wrists  D) Elbows
  3. Which of the following is the hallmark of Sjögren’s syndrome?  A) Joint deformity  B) Dry mouth and dry eyes  C) Muscle weakness  D) Skin rash
  4. Which antibody is commonly positive in systemic sclerosis?  A) Anti-Ro  B) Anti-centromere  C) Anti-Scl-70 (topoisomerase I)

 D) Anti-dsDNA

  1. Which of the following is a feature of polymyositis?  A) Distal muscle weakness  B) Proximal muscle weakness  C) Joint swelling  D) Skin rash
  2. Which medication is commonly used to treat polymyositis?  A) NSAIDs  B) Corticosteroids  C) Antibiotics  D) Methotrexate
  3. Which of the following is a common side effect of long-term corticosteroid use?  A) Osteoporosis  B) Hyperglycemia  C) Hypertension  D) All of the above
  4. Which of the following is a characteristic feature of reactive arthritis?  A) Symmetrical polyarthritis  B) Asymmetrical oligoarthritis with urethritis and conjunctivitis  C) Rash and oral ulcers  D) Malar rash

 A) MRI

 B) Temporal artery biopsy  C) X-ray  D) Joint aspiration