Good morning once again, I’m Nurhana s kalbi, and I will be presenting this topic
which is
G. Clinical significance of drug-protein binding
SLIDES
Drugs are widely used in clinical psychopharmacology, with few exceptions, that
are hepatically eliminated and circulate in the blood bound to plasma proteins. Often,
the degree of binding is high which is >90%. And This fact has led to a widespread
belief that such drugs may frequently participate in drug-binding interactions.
Coadministration of drugs can result in a highly bound drug displacing a less avidly
bound drug from its binding sites. And This reasoning simplifies a complex situation
where compensatory changes occur in the body to buffer the impact of drug-binding
interactions.
Stated here are the
SIGNIFICANCE OF DRUG PROTEIN BINDING
Absorption
Systemic solubility of drug
Distribution
Elimination
Therapy and drug targeting
Apparent volume of distribution and drug storage
Diagnosis
ABSORPTON
The absorption equilibrium is attained by transfer of free drug from the site of
administration into the systemic circulation and when the concentration in these two
compartments become equal.
However, binding of the absorbed drug to plasma proteins, decreases free drug
concentration and disturbs such an equilibrium. As we know the conventional dosage
form follow first order kinetics. So, when there is more protein binding then it disturbs
the absorption equilibrium. Therefore, the sink conditions and the concentration gradient
are re-established which now act as the driving force for further absorption. this is
particularly useful in case of ionized drugs which are transported with difficulty.
