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A comprehensive overview of the autonomic nervous system, including its two main divisions (sympathetic and parasympathetic), the structure and function of neurons, and the different types of neurotransmitters involved. It covers topics such as the role of the autonomic system in regulating involuntary bodily functions, the chemical messengers used for communication between neurons and target organs, and the implications of the neural cytoskeleton in conditions like alzheimer's disease. The document delves into the details of various neurotransmitter systems, including acetylcholine, monoamines, and amino acids, and their involvement in different physiological and behavioral processes. This comprehensive coverage of the autonomic nervous system and its underlying mechanisms makes this document a valuable resource for students and researchers in the fields of neuroscience, physiology, and psychology.
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The autonomic nervous system was first described as “cells and fibers that pass to tissues other than the skeletal muscle” (Langley, 1921). Biofeedback- a set of techniques that enable people to control typically unconscious or involuntary functions such as blood pressure. The autonomic nervous system participates in a large number of critical regulatory functions Many reflexive behaviors are carried out with the assistance of autonomic neurons.
The job of the parasympathetic nervous system is to provide rest, repair, and energy storage. “Rest and digest” response. Whereas the neurons for the sympathetic nervous system are found in the thoracic and lumbar regions of the spinal cord, the neurons for the parasympathetic nervous system are found above and below these regions
o Neuron- a cell of the nervous system that is specialized for information processing and communication. o Glia- cells in the nervous system that support the activities of neurons. o Organelle- a small structure within a cell that carries out a specific function. o Cell body / soma - the main mass of a neuron, containing the nucleus and many organelles. o Axon- the branch of a neuron usually responsible for carrying signals to other neurons. o Dendrite- the branch of a neuron that generally receives information from other neurons.
The primary task of any cell membrane is to _form a boundary between the cell and its external environment._ o Intracellular fluid- The fluid inside a cell. o Extracellular fluid- The fluid surrounding a cell. The neural membrane accomplishes its task by way of its molecular structure.
The neural membrane is made up of a double layer of phospholipids Suspended within this phospholipid membrane are a number of important protein structures that control its permeability o Ion channel- a protein structure embedded in a cell membrane that allows ions to pass without the use of additional energy. o Ion pump- a protein structure embedded in a cell membrane that uses energy to move ions across the membrane. o Voltage-dependent channel- an ion channel that opens or closes in response to the local electrical environment.
o Nucleolus- a substructure within a cell nucleus where ribosomes are produced. o Ribosome- an organelle in the cell body involved with protein synthesis.
Most neurons have a large number of branches known as dendrites. o dendritic spine- a knob on the dendrite that provides additional membrane area for the formation of synapses with other neurons. The dendritic spines of people with retardation are unusually long and thin (Purpura, 1974).
o The axon is responsible for carrying neural messages to other neurons. o Axon hillock- the cone-shaped segment of axon located at the junction of the axon and cell body that is specialized for the generation of action potentials. Axons vary substantially in diameter. Axon diameter is crucial to the speed of signaling. o Myelin- the fatty insulating material covering some axons that boosts the speed and efficiency of electrical signaling. o Local circuit neuron- a neuron that communicates with neurons in its immediate vicinity. o Projection neuron- a neuron with a very long axon that communicates with neurons in distant areas of the nervous system.
o Unipolar neuron- a neuron with one branch that extends a short distance from the cell body then splits into two branches. o Bipolar neuron- a neuron with two branches: one axon and one dendrite. o Multipolar neuron- a neuron that has multiple branches, usually one axon and numerous dendrites.
o Sensory neuron- a specialized neuron that translates incoming sensory information into electrical signals. o Motor neuron- a specialized neuron that communicates with muscles and glands. o Interneuron- a neuron that serves as a bridge between sensory and motor neurons.
Central Nervous System.
having “brain debris,” but like any cells, neurons and glia do die. Rather than leave the debris lying around where it might interfere with neural function, microglia serve as the brain’s cleanup crew.
● Major neurotransmitters fall into two classes , the small-molecule transmitters and the neuropeptides. ● small-molecule transmitter- One of a group of chemical messengers that includes amino acids and amines. ● Neuropeptide- a peptide that acts as a neurotransmitter, a neuromodulator, or a neurohormone. SMALL-MOLECULE TRANSMITTER ● acetylcholine (ACh )- a major small- molecule neurotransmitter used at the neuromuscular junction, in the autonomic nervous system, and in the central nervous system. cholinergic neurons- neurons that use ACh as their major neurotransmitter. acetyl coenzyme A (acetyl CoA)- results from the metabolic activities of mitochondria, it is present in most cells.
(Amino Acid Neurotransmitters) ● Glutamate- a major excitatory amino acid neurotransmitter; it is also the most frequently used excitatory neurotransmitter in the CNS. ● Gamma-aminobutyric acid (GABA)- a major inhibitory amino acid neurotransmitter. (GABA-A and GABA- B)
substance P - involved in the perception of pain. insulin and cholecystokinin (CCK) - are involved with digestion. oxytocin and vasopressin - act as both neurotransmitters and hormones.