ASCP American Society for Clinical Pathology BOC Medical Laboratory Scientist MLS 2024 Exa, Exams of Laboratory Practices and Management

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ASCP American Society for Clinical

Pathology BOC 2024 Exam Quiz Study

Guide 100% Pass

David Mungai [Date] [Course title]

ASCP American Society for Clinical

Pathology BOC 2024 Exam Quiz Study

Guide 100% Pass

When using an electronic cell counter, which of the following results can occur in the presence of a cold agglutination? a) increased MCV and decreased RBC b) increased MCV and normal RBC c) decreased MCV and increased MCHC d) decreased MCV and RBC - Answer>> a) increased MCV and decreased RBC Cerebrospinal fluid for glucose assay should be: a) refrigerated b) analyzed immediately c) heated to 56 degree C d) stored at room temp after centrifugation - Answer>> b) analyzed immediately The major crossmatch will detect: a) group A patient mistyped as group O b) unexpected red cell antibody in the donor unit c) Rh- neg donor unit mislabeled as Rh-Pos d) recipient antibody directly against antigens on the donor red cells - Answer>> d) recipient antibody directly against antigens on the donor red cells The anion gap is useful for quality control of laboratory reselts for a) amino acids and proteins b) blood gas anaylses c) sodium, potassium, chloride and total C02 d) calcium, phosphorus and magnesium - Answer>> c) sodium, potassium, chloride and total C A common cause of respiratory alkalosis is a) vomitting b) starvation c) asthma d) hyperventilation - Answer>> d) hyperventilation Blood is diluted 1:200, and a platelet count is performed. 180 platelets were counted in the center square millimeter on one side of the hemacytometer and 186 on the other side/ The total platelet

planned strategy that includes listening skills and ensuring an understanding with questions IgM antibodies are frequently hemolytic because of: a)the dimeric structure b) the molecule's 5 antigen binding sites c) their sedimentation coefficient of 7-15 S d) their coefficient ability to fix complement - Answer>> b) the molecule's 5 antigen binding sites A community hospital microbiology laboratory is processing significant numbers of stool cultures because of an outbreak of diarrhea following heavy rains and flooding in the county. A media that should be incorporated in the plating protocol is: a) colistin nalidixic acid for listeria b) MacConckey agar with sorbitol for Campylobacter c) mannitol salt agar for Enterococcus speices d) thiosulfate citrate bile salts sucrose for Vibrio species - Answer>> d) thiosulfate citrate bile salts sucrose for Vibrio species 80 grams of NaOH (MW=40) are how many moles? a) 1 b) 2 c) 3 d) 4 - Answer>> b) 2 An electrode has a silver/silver chloride anode and a platinum wire cathode. It is suspended in KCl solution and separated fro the blood to be analyzed by a selectively permeable membrane. Such an electrode is used to measure which of the following? a) pH b) PCO2 c) PO2 d) HCO2 - Answer>> c) PO The organism most commonly associated with neonatal purulent mentingitis is: a) Neisseria meningitidis b) Streptococcus pneumoniae c) group B streptococci d) Haemophilus influenzae - Answer>> c) group B streptococci

The volume of urine excreted in a 24-hour period by an adult patient was 300mL. This condition would be termed: a) anuria b) oliguria c)polyuria d) dysuria - Answer>> b) oliguria Amniotic fluid is tested for the concentration of lamellar bodies. This test determines: a) fetal lung maturity (FLM) b) hemolytic disease of the newborn (HDN) c) alpha-fetoprotein (AFP) d) trisomy 21 - Answer>> a) fetal lung maturity The purpose of testing with anti-A,B is to detect: a) anti-A¹ b) anti- A² c) subgroups of A d) subgroups of B - Answer>> c) subgroups of A The most important buffer pair in plasma is the a) phosphate/biphosphate pair b) hemoglobin/imidazole pair c) bicarbonate/carbonic acid pair d) sulfate/bisulfate pair - Answer>> c) bicarbonate/carbonic acid pair Evidence of active red cell regeneration may be indicated on a blood smear by: a) basophilic stippling, nucleated RBC and polychromasia b) hypochromia, macrocytes and nucleated RBC c) hypochromia, basophilic stippling and nucleated RBC d) Howell-Jolly bodies, Cabot rings and basophilic stippling - Answer>> a) basophilic stippling, nucleated RBC and polychromasia Which of the following is most closely associated with chronic myelogenous leukemia? a) ringed sideroblasts b) disseminated intravascular coagulation c) micromegakaryocytes d) Philadelphia chromosome - Answer>> d) Philadelphia chromosome All stages of neutrophils are most likely to be seen in the peripheral blood of a patient with: - Answer>> (chronic granulocytic leukemia) CML

Factors that contribute to a PCO2 electrode requiring 60- seconds to reach equilibrium include the: - Answer>> diffusion characteristics of the membrane Of the following, the disease most closely associated with pale blue inclusions in granulocytes and giant platelets is: - Answer>> May Hegglin Which of the follwing factors would make an organism appear to be more resistant on a disk diffusion sustibility test? - Answer>> too many organisms in the innoculum In spectrophotometry, the device that allows for a narrow band of wavelengths is the: - Answer>> Monochromator. Leukocyte-poor red blood cells would most likely be indicated for patients with a history of - Answer>> febrile transfusion reactions. In synovial fluid, the most characteristic microscopic finding in pseudogout is - Answer>> calcium pyrophosphate dihydrate crystals An index of precision is statistically known as the: - Answer>> coefficient of variation AHG coombs control cells : - Answer>> are coated with IgG antobody Which laboratory technique is most frequently used to diagnose and follow the course of therapy of a patient with secondary syphilis - Answer>> flocculation

The disease most often associated with elevations of lactate dehydrogenase isoenzymes 4 and 5 on electrophoresis is: - Answer>> liver disease The most appropriate screening test for hemoglobin F is: - Answer>> Kleihauer-Betke An enzyme deficiency associated with a moderate to severe hemolytic anemia after the patient is exposed to certain drugs and that is characterized by red cell inclusions formed by denatured hemoglobin is: - Answer>> G6P DH deficiency which one of the following gram-negative bacilli ferments glucose

• Answer>> Yersinia enterocolitica Photochromogens produce pigment when: - Answer>> exposed to light for 1 hour For a patient who has suffered an acute hemolytic transfusion reaction, the primary treatment should be: - Answer>> Reverse hypotension and minimize renal damage Which of the following statements most correctly describes the utility of clinical laboratory assays for tumor markers? - Answer>> tumor markers are useful in tracking the efficacy of treatment Which of the following is the most reliable test to differentiate Neisseria lactamica from Neisseria meningidis? - Answer>> lactose degradation Which of the following may be used a a positive quality control organism for the bile esculin test. - Answer>> Enterococcus faecalis

A Patient with a coagulopathy was transfused with FP24 (plasma frozen within 24 hours of collection) After infusion of 15mL, the patient experienced hypotension, shock, chest pain and difficulty in breathing. The most likely cause of the reaction is: - Answer>> anti-IgA False-positive results can occur for fecal occult blood due to the ingestion of: - Answer>> horseradish A consistently and repeatedly negative IFA-ANA is: - Answer>> strong evidence against5 untreated SLE What kind of antigen-antibody reaction would be expected if soluble antigen is added to homologous antibody? - Answer>> precipitation the Philadelphia chromosome is formed by a translocation between the: - Answer>> long arm of chromosome 22 and long arm of chromosome 9 Ten units of group A platelets were transfused to a group AB patient. The pretransfusion platelet count was 12x10^3/uL and the posttransfusion count was 18x10^3/uL. From this information, the technologist would most likely conclude that the patient: a) needs group AB platelets to be effective b) clinical data does not suggest a need for platelets c) has developed antibodies to the transfused platelets d) should receive irradiated platelets - Answer>> has developed antibodies to the transfused platelets A solution contains 20 g of solute dissolved in 0.5 L of water. What is the percentage of this solution? - Answer>> 4%

A technician is asked to clean out the chemical reagent storeroom and discard any reagents not used in the past 5 years. How should the technician proceed? - Answer>> consult MSDS sheets for proper disposal in a the clauss fibrinogen method, the time to clot formation in plasma is measured after the addition of: - Answer>> thrombin a centrifuge head has a diameter of 60 cm and spins at 3, RPM. What is the maximum achievable G force? (G=0,00001 x radius in cm x RPM) - Answer>> 2,700 G A technologist spilled 10 gallons of formaldehyde on the floor. After determining the chemical poses a significant health hazard, the first action step would be to: - Answer>> Evacuate the area A first morning sputum is received for culture of mycobacteria. It is digested and concentrated by the N-acetyl-L-cysteine alkali method. Two Lowenstein-Jensen slants are incubated in the dark at 35C with 5-10% CO2. The smears revealed acid-fast bacilli, and after 7 days no growth appears on the slants. The best explanation is: - Answer>> Cultures held for insufficient length of time. (mycobacteria are slow growers and may take up to 12 weeks) In the assay of lactate dehydrogenase, which of the following products is actually measured? - Answer>> NADH A sputum specimen from a patient with a known Klebsiella pneumonia infection is received in the lab for fungus culture. The proper procedure for handling this specimen is to: a. reject the current specimen and request a repeat culture when the bacterial organism is no longer present b. incubate culture tubes at RT in order to inhibit bacteria

Severe intravascular hemolysis is most likely caused by antibodies of which blood group system? a) ABO b) Rh c) Kell d) Duffy - Answer>> ABO urine specific gravity is an index of the ability of the kidney to: - Answer>> concentrate the urine When using the turbidity (solubility) method for detecting the presence of hemoglobin S, an incorrect interpretation may be made when there is a(n): - Answer>> increased total serum protein When cleaning up a small (5 mL) blood spill on the counter-top, the first step after donning appropriate personal protective equipment is to: - Answer>> absorb the spill with disposable absorbent material A serum sample was assayed for bilirubin at 10 AM, and the result was 12 mg/dL (205.6 μmol/L). The same sample was retested at 3 PM. The result now is 8 mg/dL (136.0 μmol/L). The most likely explanation for this discrepancy is - Answer>> the sample was exposed to light After receiving a 24-hour urine for quantitative total protein analysis, the technician must first: - Answer>> measure the total volume The causative agent of cysticercosis is: - Answer>> Taenia solium

which of the following is a characteristic of polyagglutinable red cells - Answer>> are agglutinated by most adult sera The purpose of a low-dose irradiation of blood components is to: a) prevent posttransfusion purpura b) prevent GVHD c) sterilize components d) prevent noncardiogenic pulmonary edema - Answer>> prevent graft-vs-host GVHD the genus of virus associated with anogenital wart, cervical dysplasia and neoplasia is: - Answer>> papillomavirus n emphysema patient suffering from fluid accumulation in the alveolar spaces is likely to be in what metabolic state? - Answer>> respiratory acidosis An automated CK assay gives a reading that is above the limits of linearity. A dilution of the serum sample is made by adding 1 mL of serum to 9 mL of water. The instrument now reads 350 U/L. the correct report on the undiluted serum should be: - Answer>> 3500 U/L Precautions for health care workers dealing with patients or patient specimens include: - Answer>> prompt cleaning of blood spills with a disinfectant solution such as sodium hypochlorite. Which of the following is most likely to be ordered in addition to serum calcium to determine the cause of tetany? - Answer>> magnesium Aspartate amino transferase (AST) is characteristically elevated in diseases of the - Answer>> liver

.A 25 year old woman is seen by a physician because of Raynaud's phenomenon, myalgias, arthralgias, and difficulty in swallowing. There is no evidence of renal disease. An ANA titer is 1:5120 with a speckled pattern with mitotic. Which of the following is also likely to be found in this patient? - Answer>> high-level ribonucleoprotein (RNP) antibody The direction in which albumin migrates (ie. toward anode or cathode) during electrophoretic separation os serum proteins, at pH 8.6, is determined by: - Answer>> the ionization of the carboxyl groups, yielding a net negative charge A urine culture had the following culture results: -sheep blood: swarming -CNA: no growth -Mac: 1. >100,000 CFU/mL nonlactose-fermenter

2. 100,000 CFU/mL nonlactose-fermenter with red pigment The isolates from Mac had the following biochemical reactions TEST ISO 1 ISO TSI alk/acid alk/acid urea pos neg TDA pos neg H2S pos neg - Answer>> Proteus mirabilis and Serratia marcescens The tau isoform of transferrin is a carbohydrate deficient protein found only in: A. CSF B. sweat C. amniotic fluid D. semen - Answer>> CSF

Flocculation tests for syphilis use antigen composed of - Answer>> cardiolipin and lecithin The Liley method of predicting the severity of hemolytic disease of the newborn is based on the amniotic fluid: - Answer>> change in optical density measured at 450nm A low concentration of serum phosphorus is commonly found in - Answer>> patients who are receiving carbohydrate hyperalimentation In a relationship testing case, the child has a genetic marker that is absent in the mother and cannot be demonstrated in the alleged father. What type of paternity exclusion is this known as?

• Answer>> Direct Routine screening of urine samples for glycosuria is performed primarily to detect: - Answer>> glucose DNA-based testing for the presence of MRSA uses PCR with primers specific for which gene? - Answer>> mecA The following data were calculated on a series of 30 determinations of serum uric acid control: mean=5.8 mg/dL, 1 standard deviation=0.15 mg/dL. If the confidence limits are set at +or-2 SD, which of the following represents the allowable limits for the control? - Answer>> 5.50-6.10 mg/dL A fluid sample waas collected by throcentesis. A serum sample was collected immediately afterward. The LD fluid to serum ratio was 0.9. there were 5,000 WBC/uL, with 75% PMNs Which of the following describes this fluid. - Answer>> Plural effusion exudate

A nonchromogen that grows best at 42 degree C and is highly resistant to antibiotics is: - Answer>> Mycobaterium xenopi Microscope analysis of a urine specimen yields a moderate amount of red blood cells in spite of a negative result for occult blood using a reagent strip. The technologist should determine if this patient has taken: - Answer>> vitamine C Nephelometers measure light: - Answer>> a scattered at a right angle to the light path A first morning sputum is received for acid-fast culture. The specimen is centrifuged and the sediment is inoculated on Two Lowenstein-Jensen slants, which are incubated at 35C with 5- 10% CO2. After 1 week, the slants show abundant growth over the entire surface. Strains reveal gram-negative bacilli. To avoid this problem: - Answer>> decontaminate the specimen with sodium hydroxide Polarized light can often be used to differentiate between: - Answer>> fibers and mucus clumps Which of the following clinical disorders is associated with the greatest elevation of lactate dehydrogenase isoenzyme 1? - Answer>> pernicious anemia