BIMM134, Midterm I
Midterm I, Biology of Cancer, Prof. Randall Johnson, Spring 2004
ANSWER ALL QUESTIONS! THERE MAY BE MULTIPLE POSSIBLE ANSWERS:
CHOOSE THE BEST ANSWER!
1. Migration of tumor cells to new sites is
metastasis
2. F. Peyton Rous found that fluid filtered from chicken tumor cells was able to induce
new tumors in other chickens. This was an example of
a virally-initiated tumor
3. Inversion of chromosome 16 is associated with certain cases of
AML
4. CBF and are transcription factors involved in regulating
myeloid cell differentiation
5. X-inactivation of G6PD alleles
none of the above
6. VHL is
a tumor suppressor
7. HIF1 levels are thought to be oxygen sensitive due to
modification by oxygen-dependent hydroxylases
8. Malignant cells are
neoplastic
9. Cancer cells can transform neighboring cells by interactions within a basement
membrane.
False
10. Jean Astruc found that
the humoral theory of cancer was untrue
11. Endothelial cells
have receptors for angiogenic factors
12. Dedifferentiation is a process undergone by some cancer cells
when they lose cellular markers of tissue specificity
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