1) Which of the following conditions can be treated with Dopamine receptor antagonists? (5 ea)
a) Epilepsy
b) Parkinson’s Disease
c) Schizophrenia
d) Angina pectoris
e) Nausea/Vomiting
f) Diarrhea
2) Describe two clinical uses (+ mechanism) for the synthetic prostaglandin Misoprostol (10)
3) Which anti-diabetic drug group acts via the nuclear receptor PPAR? Can these drugs be
used for type I diabetes (explain!)? (10)
4) What is the “Minimal Alveolar Concentration (MAC)”? How does the MAC relate to the lipophilicity
of the drug? (10)
5) Aspirin is contraindicated in which of the following conditions (5 ea)
a) Angina pectoris
b) Bronchial asthma
c) Hypertension
d) Arthritis
e) Gastritic ulcers
f) Bradycardia
6) The effects of which inhibitory neurotransmitter are intensified by alcohol? Which two drug
classes have a strong synergistic sedating effect with alcohol based on this mechanism?
Explain! (15)
7) During an outpatient procedure the physician accidentally injects lidocaine directly into the
bloodstream. Within a few seconds the patient goes into cardiac arrest. WHY? (15)
8) Which drug (group) reduces preload and afterload to alleviate symptoms of Angina pectoris?
Briefly describe the basis for the efficacy (10)
9) What are the specific indications for the opioid receptor antagonists Naloxone and
Naltrexone? (10)
10)Both Ranitidine and Lansoprazole are used to reduce stomach acid production. (15)
a) How do these drugs work (explain the mechanism)?
b) Which drug is likely to be more effective (explain your conclusion!)?
11)Provide two distinct examples for the clinical use of estrogen receptor antagonists!
Name one drug in each group and describe the basis for their efficacy (20)
12)Provide an example of a drug (group) where addition of halogen atoms leads to increased
potency and/or efficacy of the drug! (5)
13)Provide an example of a (natural or synthetic) opiate derivative that is NOT used for
analgetic purposes (name the drug and it’s use)! (10)
