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The Citric Acid Cycle - Biochemistry - Lecture Notes

Lecture Notes, Biochemistry

Post: November 20th, 2012
Description
The Citric Acid Cycle, Citrate Synthase, Isocitrate Dehydrogenase, Pyruvate Dehydrogenase, Dihydrolipoyl Transacetylase, Dihydrolipoyl Dehydrogenase, Succinate Dehydrogenase, Fumarase Catalyzes, Malate Dehydrogenase, Net Reaction of the Citric Acid Cycle are few points from this lecture notes. If you are looking for complete set of lectures on biochemistry, you can find it in my documents section.
The Citric Acid Cycle, Citrate Synthase, Isocitrate Dehydrogenase, Pyruvate Dehydrogenase, Dihydrolipoyl Transacetylase, Dihydrolipoyl Dehydrogenase, Succinate Dehydrogenase, Fumarase Catalyzes, Malate Dehydrogenase, Net Reaction of the Citric Acid Cycle are few points from this lecture notes. If you are looking for complete set of lectures on biochemistry, you can find it in my documents section.
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The Citric Acid Cycle I. Citrate Synthase CO2CO CH2 CO2O The first reaction of the citric acid cycle is the condensation of acetyl-CoA and oxaloacetate to form citrate and CoA-SH. The enzyme that catalyzes this reaction is called citrate synthase. ∆Go’ = -32.2 kJ/mol + H3C C SCoA CoASH + H+ CO2CH2 HO C CO2CH2 CO2+ The change in free energy based on the steady state concentrations of oxaloacetate, acetyl-CoA and citrate in the mitochondria of isolated from pig hearts is: ∆G = -53.9 kJ/mol A very exergonic reaction and irreversible. C C H H H 2C - CoAS NH O H O - Asp375 O CO2 O O Asp375 O CO2 - HN CH2 His274 The mechanism of citrate synthase is shown to the left. In the active site of the enzyme we have two histidines and an aspartate which function as general acids and bases during catalysis. The first step is to generate an enol of acetyl-CoA. Asp-375 functions as a general base abstracting a proton for the methyl group of Acetyl-CoA. His-274 concertedly functions as..

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