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Genomics and Gene Recognition - Bioinformatics - Lecture Slides

Slides, Bioinformatics

Post: April 23th, 2013
Description
Main points of this lecture are: Genomics and Gene Recognition, Eukaryotes, Prokaryotic Genomes, Gene Structure, Single Circular Chromosome, Promoter Elements, Assemblies of Proteins, Specific Nucleotide Sequences, Polycistronic Rna Molecule
Main points of this lecture are: Genomics and Gene Recognition, Eukaryotes, Prokaryotic Genomes, Gene Structure, Single Circular Chromosome, Promoter Elements, Assemblies of Proteins, Specific Nucleotide Sequences, Polycistronic Rna Molecule
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Contents
Genomics and Gene Recognition Docsity.com Genomics and Gene Recognition • How do we recognize the genes given the raw sequence data? • Two different cases: – Prokaryotes: relatively easy – Eukaryotes: relatively difficult • Much “junk DNA” to search through • Signals determine the beginnings and ends of genes – Need to find the signals Docsity.com Prokaryotic Genomes • Genomic information of prokaryotes dedicated mainly to basic tasks – Make and replicate DNA – Make new proteins – Obtain and store energy • Over 60 prokaryotic genomes have been completely sequenced since mid-1990s Docsity.com Prokaryotic Genomes • Recall - prokaryotes have a single circular chromosome • Also - no cell nucleus, therefore no splicing out of introns • Therefore, prokaryotic gene structure is quite simple Promoter region Translational start site (AUG) Translational stop site Open Reading Frame Transcriptional start site Operator sequence Transcriptional stop site..

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